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KMID : 0360119920140030245
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
1992 Volume.14 No. 3 p.245 ~ p.251
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Experimental study on tissue response of demineralized xenogenic bone matrix in extraskeletal site
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Abstract
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To evaluate the tissue response of demineralized and undfimineralized xenogeneic bone-martrix graft in exraskeletal site, we prepared human bone as a implant matrix, and outbred mouse as a recipient.
Before clinical application of bank bone of human in Wonwang university, we should confirm the allogeneic bone grafts as a biologically useful bone graft substitutes, obtanined from the patients receiving oral and maxillofacial surgery.
The clinical evaluation and histologic studies showd that both (demineralized and undemineralized) xenogeneic bone matrix grafts were not rejected and that they seemed to stimulate new bone formation at the transplanation site.
Undemineralized xenogeneic bone martrix grafts showed minimal bone induction and gradual demineralization with slow resorption and showed that the differentiation of cells showing fibroblastic activity adjacent to the soft tissue were slowly and
less
frequently than demineralized bone.
Characteristical differences between the demineralized and undemineralized matrix were the appearance of foreigh body giant cells (multinucleated giant cells) and the evidence of slow resorption in undemineralized bone matrix.
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KEYWORD
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